The effect of geometric isomerism on the anticancer activity of the monofunctional platinum complex
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Author(s)
Zhou, Wen
Almeqdadi, Mohammad
Xifaras, Michael
Riddell, Imogen Anne
Yilmaz, Omer
Lippard, Stephen J.
Date Issued
February 2018
Journal
Chemical Communications
Publisher
Royal Society of Chemistry (RSC)
Citation
Zhou, Wen et al. “The Effect of Geometric Isomerism on the Anticancer Activity of the Monofunctional Platinum Complex Trans-[Pt(NH₃)₂(phenanthridine)Cl]NO₃.” Chemical Communications 54, 22 (2018): 2788–2791 © 2018 The Royal Society of Chemistry
Version
Final published version
Abstract
A trans-DDP based monofunctional phenanthridine Pt(ii) complex was synthesized and characterized. Its anticancer activity was studied in vitro on a panel of human cancer cell lines and mouse intestinal cancer organoids. This complex displays significant antitumor properties, with a different spectrum of activity than that of classic bifunctional cross-linking agents like cisplatin.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
Koch Institute for Integrative Cancer Research at MIT
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Creative Commons Attribution 4.0 International License
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DOI of Published Version
https://doi.org/10.1039/C8CC00393A
