Ultrasound‐Responsive Aqueous Two‐Phase Microcapsules for On‐Demand Drug Release
Name
ange.202116515.pdf
Description
Accepted version
Size
1016.86 KB
Format
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Checksum (MD5)
03e18425898ee27eb2f0c59252fccba2
Author(s)
Field, Rachel D
Jakus, Margaret A
Chen, Xiaoyu
Human, Kelia
Zhao, Xuanhe
Chitnis, Parag V
Sia, Samuel K
Date Issued
May 9, 2022
Journal
Angewandte Chemie
Publisher
Wiley
Citation
Field, Rachel D, Jakus, Margaret A, Chen, Xiaoyu, Human, Kelia, Zhao, Xuanhe et al. 2022. "Ultrasound‐Responsive Aqueous Two‐Phase Microcapsules for On‐Demand Drug Release." Angewandte Chemie, 134 (20).
Version
Author's final manuscript
Abstract
Traditional implanted drug delivery systems cannot easily change their release profile in real time to respond to physiological changes. Here we present a microfluidic aqueous two‐phase system to generate microcapsules that can release drugs on demand as triggered by focused ultrasound (FUS). The biphasic microcapsules are made of hydrogels with an outer phase of mixed molecular weight (MW) poly(ethylene glycol) diacrylate that mitigates premature payload release and an inner phase of high MW dextran with payload that breaks down in response to FUS. Compound release from microcapsules could be triggered as desired; 0.4 μg of payload was released across 16 on‐demand steps over days. We detected broadband acoustic signals amidst low heating, suggesting inertial cavitation as a key mechanism for payload release. Overall, FUS‐responsive microcapsules are a biocompatible and wirelessly triggerable structure for on‐demand drug delivery over days to weeks.
MIT Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1002/ange.202116515
