Low-cost plug and play photochemistry reactor
Name
1-s2.0-S2468067217300524-main.pdf
Description
Published version
Size
737.95 KB
Format
Adobe PDF
Checksum (MD5)
a54ff8241370a7117b043d4cfeea88b1
Author(s)
Dellal, David
Yee, Emma
Lathwal, Shefali
Sikes, Hadley
Gomez-Marquez, Jose
Date Issued
2018
Journal
HardwareX
Publisher
Elsevier BV
Version
Final published version
Abstract
© 2017 The Authors Polymerization-based amplification (PBA) uses a visible-light photopolymerization reaction for rapid, low-cost signal amplification and colorimetric detection in disease diagnostics. PBA is particularly useful for point-of-care testing (POCT) in the developing world where laboratory infrastructure and access to advanced technologies may be limited. To date, PBA has required expensive (∼5K USD), desktop-based light sources to drive these photopolymerization reactions, which has limited its use in limited-resource areas and for POCT applications. Here, we present a portable, lightweight, and low-cost device that can generate light of the intensity and wavelengths required to perform the PBA reactions rapidly (<100 s) with minimal energy consumption. We developed analog and digital versions of the device that meet these criteria and can operate on their own without the requirement of a computer to run necessary software. Lastly, they both have the added functionality to dim the intensity of the LED to allow customization of the reaction conditions to the needs of individual assays.
MIT Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Chemical Engineering
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/J.OHX.2017.11.001
