In Vitro Modeling of Mechanics in Cancer Metastasis
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acsbiomaterials.7b00041.pdf
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2.02 MB
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Adobe PDF
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Author(s)
Malandrino, Andrea
Kamm, Roger Dale
Moeendarbary, Emadaldin
Date Issued
May 2017
Journal
ACS Biomaterials Science & Engineering
Publisher
American Chemical Society (ACS)
Citation
Malandrino, Andrea, Roger D. Kamm, and Emad Moeendarbary. “In Vitro Modeling of Mechanics in Cancer Metastasis.” ACS Biomaterials Science & Engineering 4, no. 2 (June 2017): 294–301.
Version
Final published version
Abstract
In addition to a multitude of genetic and biochemical alterations, abnormal morphological, structural, and mechanical changes in cells and their extracellular environment are key features of tumor invasion and metastasis. Furthermore, it is now evident that mechanical cues alongside biochemical signals contribute to critical steps of cancer initiation, progression, and spread. Despite its importance, it is very challenging to study mechanics of different steps of metastasis in the clinic or even in animal models. While considerable progress has been made in developing advanced in vitro models for studying genetic and biological aspects of cancer, less attention has been paid to models that can capture both biological and mechanical factors realistically. This is mainly due to lack of appropriate models and measurement tools. After introducing the central role of mechanics in cancer metastasis, we provide an outlook on the emergence of novel in vitro assays and their combination with advanced measurement technologies to probe and recapitulate mechanics in conditions more relevant to the metastatic disease.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Mechanical Engineering
Terms of Use
Creative Commons Attribution 4.0 International License
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DOI of Published Version
https://doi.org/10.1021/ACSBIOMATERIALS.7B00041
