Enhanced immune activation linked to endotoxemia in HIV-1 seronegative men who have sex with men
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Lauffenburger_Enhanced immune.pdf
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Author(s)
Palmer, Christine D.
Tomassilli, Julia
Sirignano, Michael
Romero-Tejeda, Marisol
Arnold, Kelly B.
Che, Denise
Lauffenburger, Douglas A.
Jost, Stephanie
Allen, Todd
Mayer, Kenneth H.
Alternative Title
Enhanced immune activation linked to endotoxemia in HIV-1 seronegative MSM
Date Issued
September 2014
Journal
AIDS
Publisher
Lippincott Williams & Wilkins
Citation
Palmer, Christine D., Julia Tomassilli, Michael Sirignano, Marisol Romero-Tejeda, Kelly B. Arnold, Denise Che, Douglas A. Lauffenburger, et al. “Enhanced Immune Activation Linked to Endotoxemia in HIV-1 Seronegative MSM.” AIDS 28, no. 14 (2014): 2162–2166.
Version
Author's final manuscript
Abstract
This study assessed cellular and soluble markers of immune activation in HIV-1 seronegative MSM. MSM immune profiles were characterized by an increased expression of CD57 on T cells and endotoxemia. Endotoxin presence was linked to recent high-risk exposure and associated with elevated cytokine levels and decreased CD4+/CD8+ T cell ratios. Taken together, these data show elevated levels of inflammation linked to periods of endotoxemia resulting in a significantly different immune phenotype in a subset of MSM at a high risk of HIV-1 acquisition.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1097/qad.0000000000000386
