Simultaneous Identification of Neutral and Anionic Species in Complex Mixtures without Separation
Name
Swager_Simultaneous identification.pdf
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1.08 MB
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04a362654da6bf415c490157ba8accb7
Author(s)
Zhao, Yanchuan
Chen, Lily
Swager, Timothy M
Date Issued
January 2016
Journal
Angewandte Chemie International Edition
Publisher
Wiley Blackwell
Citation
Zhao, Yanchuan, Lily Chen, and Timothy M. Swager. “Simultaneous Identification of Neutral and Anionic Species in Complex Mixtures without Separation.” Angewandte Chemie International Edition 55.3 (2016): 917–921.
Version
Author's final manuscript
Abstract
A chemosensory system is reported that operates without the need for separation techniques and is capable of identifying anions and structurally similar bioactive molecules. In this strategy, the coordination of analytes to a metal complex with an open binding cleft generates “static structures” on the NMR timescale. Unique signals are created by strategically placing fluorine atoms in close proximity to bound analytes so that small structural differences induce distinct 19F NMR shifts that can be used to identify each analyte. The utility of this method is illustrated by quantifying caffeine levels in coffee, by identifying ingredients in tea and energy drinks, and by discriminating between multiple biogenic amines with remote structural differences six carbon atoms away from the binding site. We further demonstrate the simultaneous identification of multiple neutral and anionic species in a complex mixture.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1002/anie.201508085
