The functions and consequences of force at kinetochores
Name
Rago-2013-The functions and co.pdf
Size
1.39 MB
Format
Adobe PDF
Checksum (MD5)
95544d8da46b31d5cf892ac4fa63bdd1
Author(s)
Rago, Florencia
Cheeseman, Iain M
Date Issued
March 2013
Journal
Journal of Cell Biology
Publisher
Rockefeller University Press, The
Citation
Rago, F., and I. M. Cheeseman. “The Functions and Consequences of Force at Kinetochores.” The Journal of Cell Biology 200.5 (2013): 557–565.
Version
Final published version
Abstract
Chromosome segregation requires the generation of force at the kinetochore—the multiprotein structure that facilitates attachment of chromosomes to spindle microtubules. This force is required both to move chromosomes and to signal the formation of proper bioriented attachments. To understand the role of force in these processes, it is critical to define how force is generated at kinetochores, the contributions of this force to chromosome movement, and how the kinetochore is structured and organized to withstand and respond to force. Classical studies and recent work provide a framework to dissect the mechanisms, functions, and consequences of force at kinetochores.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Massachusetts Institute of Technology. School of Science
Whitehead Institute for Biomedical Research
Terms of Use
Creative Commons Attribution 3.0
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1083/jcb.201211113
