Human pathogenic RNA viruses establish noncompeting lineages by occupying independent niches
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pnas.2121335119.pdf
Description
Published version
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1.69 MB
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Author(s)
Mutz, Pascal
Rochman, Nash D
Wolf, Yuri I
Faure, Guilhem
Zhang, Feng
Koonin, Eugene V
Date Issued
June 7, 2022
Journal
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Citation
Mutz, Pascal, Rochman, Nash D, Wolf, Yuri I, Faure, Guilhem, Zhang, Feng et al. 2022. "Human pathogenic RNA viruses establish noncompeting lineages by occupying independent niches." Proceedings of the National Academy of Sciences, 119 (23).
Version
Final published version
Abstract
Significance
Numerous pathogenic viruses are endemic in humans and cause a broad variety of diseases, but what is their potential for causing new pandemics? We show that most human pathogenic RNA viruses form multiple, cocirculating lineages with low turnover rates. These lineages appear to be largely noncompeting and occupy distinct epidemiological niches that are not regionally or seasonally defined, and their persistence appears to stem from limited outbreaks in small communities so that only a small fraction of the global susceptible population is infected at any time. However, due to globalization, interaction and competition between lineages might increase, potentially leading to increased diversification and pathogenicity. Thus, endemic viruses appear to merit global attention with respect to the prevention of future pandemics.
Numerous pathogenic viruses are endemic in humans and cause a broad variety of diseases, but what is their potential for causing new pandemics? We show that most human pathogenic RNA viruses form multiple, cocirculating lineages with low turnover rates. These lineages appear to be largely noncompeting and occupy distinct epidemiological niches that are not regionally or seasonally defined, and their persistence appears to stem from limited outbreaks in small communities so that only a small fraction of the global susceptible population is infected at any time. However, due to globalization, interaction and competition between lineages might increase, potentially leading to increased diversification and pathogenicity. Thus, endemic viruses appear to merit global attention with respect to the prevention of future pandemics.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
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DOI of Published Version
https://doi.org/10.1073/pnas.2121335119
