Nanoparticles for targeting the infarcted heart
Name
Anderson_Nanoparticles for.pdf
Size
1.04 MB
Format
Adobe PDF
Checksum (MD5)
b2bd2acfab2442ef6644cbf8475e596e
Author(s)
Dvir, Tal
Bauer, Michael
Schroeder, Avi
Tsui, Jonathan H.
Anderson, Daniel G.
Langer, Robert
Liao, Ronglih
Kohane, Daniel S.
Date Issued
September 2011
Journal
Nano Letters
Publisher
American Chemical Society (ACS)
Citation
Dvir, Tal et al. “Nanoparticles Targeting the Infarcted Heart.” Nano Letters 11.10 (2011): 4411–4414.
Version
Author's final manuscript
Abstract
We report a nanoparticulate system capable of targeting the heart after myocardial infarction (MI). Targeting is based on overexpression of angiotensin II type 1 (AT1) receptor in the infarcted heart. Liposomes 142 nm in diameter were conjugated with a ligand specific to AT1. The nanoparticles were able to specifically target cardiac cells in vitro, and in the infarcted heart after intravenous injection in vivo. This system may be useful for delivering therapeutic agents specifically to the infarcted heart.
Description
Author's Manuscript: 2012 October 12.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1021/nl2025882
