A role for nickel-iron cofactors in biological carbon monoxide and carbon dioxide utilization
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Drennan_A role.pdf
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1.55 MB
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981028224d88c5542c6a46c91257f344
Author(s)
Kung, Yan
Drennan, Catherine L
Date Issued
December 2010
Journal
Current Opinion in Chemical Biology
Publisher
Elsevier
Citation
Kung, Yan, and Catherine L Drennan. “A Role for Nickel–iron Cofactors in Biological Carbon Monoxide and Carbon Dioxide Utilization.” Current Opinion in Chemical Biology 15.2 (2011): 276–283.
Version
Author's final manuscript
Abstract
Ni–Fe containing enzymes are involved in the biological utilization of carbon monoxide, carbon dioxide, and hydrogen. Interest in these enzymes has increased in recent years due to hydrogen fuel initiatives and concerns over development of new methods for CO2 sequestration. One Ni–Fe enzyme called carbon monoxide dehydrogenase (CODH) is a key player in the global carbon cycle and carries out the interconversion of the environmental pollutant CO and the greenhouse gas CO[subscript 2]. The Ni–Fe center responsible for this important chemistry, the C-cluster, has been the source of much controversy, but several recent structural studies have helped to direct the field toward a unifying mechanism. Here we summarize the current state of understanding of this fascinating metallocluster.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Massachusetts Institute of Technology. Department of Chemistry
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Creative Commons Attribution-Noncommercial-Share Alike 3.0
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DOI of Published Version
https://doi.org/10.1016/j.cbpa.2010.11.005
