The synthesis and applications of a biaryl-based asymmetric phosphine ligand
Name
61858035-MIT.pdf
Description
Full printable version
Size
2.14 MB
Format
Adobe PDF
Checksum (MD5)
f1a9bcd88ad65aad49019f44a4d849fd
Author(s)
Hirai, Satoko
Advisor(s)
Stephen L. Buchwald.
Date Issued
2005
Publisher
Massachusetts Institute of Technology
Abstract
The asymmetric biaryl backbone of a dialkylbiphenyl phosphine ligand was developed, synthesized, and resolved. The application of the chiral phosphine ligand to the asymmetric Suzuki-Miyaura cross-coupling reaction was also investigated. This phosphine ligand has yielded promising results in the asymmetric Suzuki-coupling of hindered boronic acids with the electron-rich aryl bromide, 1-bromo-2- methoxynaphthalene, to synthesize biaryls in modest enantioselectivity.
Description
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2005.
Includes bibliographical references.
Subjects
Chemistry.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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