NAD + supplementation rejuvenates aged gut adult stem cells
Name
Igarashi_et_al-2019-Aging_Cell.pdf
Description
Published version
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918.26 KB
Format
Adobe PDF
Checksum (MD5)
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Author(s)
Igarashi, Masaki
Miura, Masaomi
Williams, Eric O
Jaksch, Frank
Kadowaki, Takashi
Yamauchi, Toshimasa
Guarente, Leonard Pershing
Date Issued
March 2019
Journal
Aging Cell
Publisher
Wiley
Citation
Igarashi, Masaki et al. "NAD + supplementation rejuvenates aged gut adult stem cells." Aging Cell 18,3 (June 2019): e12935 © 2019 The Author(s).
Version
Final published version
Abstract
The tissue decline due to aging is associated with the deterioration of adult stem cell function. Here we show the number and proliferative activity of intestinal stem cells (ISCs) but not Paneth cells decline during aging, as does ISC function assessed ex vivo. Levels of SIRT1 and activity of mTORC1 also decline with aging. The treatment with the NAD(+) precursor nicotinamide riboside (NR) rejuvenates ISCs from aged mice and reverses an impaired ability to repair gut damage. The effect of NR is blocked by the mTORC1 inhibitor rapamycin or the SIRT1 inhibitor EX527. These findings demonstrate that small molecules affecting the NAD/SIRT1/mTORC1 axis may guide a translational path for maintenance of the intestine during aging. Keywords: aging; intestinal stem cells; NAD+; nicotinamide riboside
MIT Department
Massachusetts Institute of Technology. Department of Biology
Paul F. Glenn Center for Biology of Aging Research (Massachusetts Institute of Technology)
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution 4.0 International license
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1111/acel.12935
