Tuning an activator-repressor clock employing retroactivity
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Del Vecchio_Tuning an activator.pdf
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Author(s)
Rosenberg, Alexander
Jayanthi, Shridhar
Del Vecchio, Domitilla
Date Issued
June 2010
Journal
Proceedings of the 2011 American Control Conference (ACC)
Publisher
American Automatic Control Council
Citation
Rosenberg, Alexander, Shridhar Jayanthi and Domitilla Del Vecchio. "Tuning an activator-repressor clock employing retroactivity" In 2011 American Control Conference on O'Farrell Street, San Francisco, CA, USA June 29 - July 01, 2011. Proceedings. IEEE. 2011.
Version
Author's final manuscript
Abstract
Activator-repressor systems have been shown to
be capable of oscillations and are therefore an important clock
motif in the field of Synthetic and Systems Biology. In this paper,
we propose a method to regulate oscillatory behavior in such
systems by the addition of DNA binding sites for the proteins
involved in the clock network. We show that the retroactivity
effect caused by this addition can effectively change the relative
timescales among the protein dynamics and impact the behavior
of the clock. We also employ root locus analysis to obtain a
graphical interpretation of the results.
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Massachusetts Institute of Technology. Department of Mechanical Engineering
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DOI of Published Version
http://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=5991401
