Inter-individual variation in DNA repair capacity: A need for multi-pathway functional assays to promote translational DNA repair research
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Samson_Inter-individual.pdf
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Author(s)
Nagel, Zachary D.
Chaim, Isaac Alexander
Samson, Leona D
Date Issued
April 2014
Journal
DNA Repair
Publisher
Elsevier
Citation
Nagel, Zachary D., Isaac A. Chaim, and Leona D. Samson. “Inter-Individual Variation in DNA Repair Capacity: A Need for Multi-Pathway Functional Assays to Promote Translational DNA Repair Research.” DNA Repair 19 (July 2014): 199–213.
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Author's final manuscript
Abstract
Why does a constant barrage of DNA damage lead to disease in some individuals, while others remain healthy? This article surveys current work addressing the implications of inter-individual variation in DNA repair capacity for human health, and discusses the status of DNA repair assays as potential clinical tools for personalized prevention or treatment of disease. In particular, we highlight research showing that there are significant inter-individual variations in DNA repair capacity (DRC), and that measuring these differences provides important biological insight regarding disease susceptibility and cancer treatment efficacy. We emphasize work showing that it is important to measure repair capacity in multiple pathways, and that functional assays are required to fill a gap left by genome wide association studies, global gene expression and proteomics. Finally, we discuss research that will be needed to overcome barriers that currently limit the use of DNA repair assays in the clinic.
MIT Department
Massachusetts Institute of Technology. Center for Environmental Health Sciences
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Biology
Koch Institute for Integrative Cancer Research at MIT
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DOI of Published Version
https://doi.org/10.1016/j.dnarep.2014.03.009
