Hydrogel dressings with intrinsic antibiofilm and antioxidative dual functionalities accelerate infected diabetic wound healing
Name
s41467-024-44968-y.pdf
Description
Published version
Size
5.45 MB
Format
Adobe PDF
Checksum (MD5)
0debdd60cd013c98bd2e082423617e02
Author(s)
Pranantyo, Dicky
Yeo, Chun Kiat
Wu, Yang
Fan, Chen
Xu, Xiaofei
Yip, Yun Sheng
Vos, Marcus Ivan Gerard
Mahadevegowda, Surendra H
Lim, Priscilla Lay Keng
Yang, Liang
Date Issued
February 1, 2024
Journal
Nature Communications
Publisher
Springer Science and Business Media LLC
Citation
Pranantyo, D., Yeo, C.K., Wu, Y. et al. Hydrogel dressings with intrinsic antibiofilm and antioxidative dual functionalities accelerate infected diabetic wound healing. Nat Commun 15, 954 (2024).
Version
Final published version
Abstract
Chronic wounds are often infected with biofilm bacteria and characterized by high oxidative stress. Current dressings that promote chronic wound healing either require additional processes such as photothermal irradiation or leave behind gross amounts of undesirable residues. We report a dual-functionality hydrogel dressing with intrinsic antibiofilm and antioxidative properties that are synergistic and low-leaching. The hydrogel is a crosslinked network with tethered antibacterial cationic polyimidazolium and antioxidative N-acetylcysteine. In a murine diabetic wound model, the hydrogel accelerates the closure of wounds infected with methicillin-resistant Staphylococcus aureus or carbapenem-resistant Pseudomonas aeruginosa biofilm. Furthermore, a three-dimensional ex vivo human skin equivalent model shows that N-acetylcysteine promotes the keratinocyte differentiation and accelerates the re-epithelialization process. Our hydrogel dressing can be made into different formats for the healing of both flat and deep infected chronic wounds without contamination of the wound or needing other modalities such as photothermal irradiation.
MIT Department
Singapore-MIT Alliance in Research and Technology (SMART)
Massachusetts Institute of Technology. Department of Chemical Engineering
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Creative Commons Attribution
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DOI of Published Version
10.1038/s41467-024-44968-y
