Monotopic Membrane Proteins Join the Fold
Name
nihms-1509754.pdf
Description
Accepted version
Size
1.5 MB
Format
Adobe PDF
Checksum (MD5)
14b2afcc40af048771038fa9dec4884f
Author(s)
Entova, Sonya.
Imperiali, Barbara
Date Issued
January 2019
Journal
Trends in biochemical sciences
Publisher
Elsevier BV
Citation
Allen, Karen N. et al. “Monotopic Membrane Proteins Join the Fold.” Trends in biochemical sciences 44 (2019): 7-20 © 2019 The Author(s)
Version
Author's final manuscript
Abstract
Monotopic membrane proteins, classified by topology, are proteins that embed into a single face of the membrane. These proteins are generally underrepresented in the Protein Data Bank (PDB), but the past decade of research has revealed new examples that allow the description of generalizable features. This Opinion article summarizes shared characteristics including oligomerization states, modes of membrane association, mechanisms of interaction with hydrophobic or amphiphilic substrates, and homology to soluble folds. We also discuss how associations of monotopic enzymes in pathways can be used to promote substrate specificity and product composition. These examples highlight the challenges in structure determination specific to this class of proteins, but also the promise of new understanding from future study of these proteins that reside at the interface.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Massachusetts Institute of Technology. Department of Chemistry
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/J.TIBS.2018.09.013
