The landscape of somatic copy-number alteration across human cancers
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Lander_The landscape.pdf
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2.01 MB
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959960773e931fda6a945134e1d50c17
Author(s)
Lander, Eric Steven
Date Issued
February 2010
Journal
Nature
Publisher
Nature Publishing Group
Citation
Beroukhim, Rameen et al. “The Landscape of Somatic Copy-number Alteration Across Human Cancers.” Nature 463.7283 (2010): 899–905. Web.
Version
Author's final manuscript
Abstract
A powerful way to discover key genes with causal roles in oncogenesis is to identify genomic regions that undergo frequent alteration in human cancers. Here we present high-resolution analyses of somatic copy-number alterations (SCNAs) from 3,131 cancer specimens, belonging largely to 26 histological types. We identify 158 regions of focal SCNA that are altered at significant frequency across several cancer types, of which 122 cannot be explained by the presence of a known cancer target gene located within these regions. Several gene families are enriched among these regions of focal SCNA, including the BCL2 family of apoptosis regulators and the NF-κΒ pathway. We show that cancer cells containing amplifications surrounding the MCL1 and BCL2L1 anti-apoptotic genes depend on the expression of these genes for survival. Finally, we demonstrate that a large majority of SCNAs identified in individual cancer types are present in several cancer types.
Description
available in PMC 2010 August 18.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Whitehead Institute for Biomedical Research
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike 3.0
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DOI of Published Version
https://doi.org/10.1038/nature08822
