Development of schemas revealed by prior experience and NMDA receptor knock-out
Name
Tonegawa_Development of schemas.pdf
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4.94 MB
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Adobe PDF
Checksum (MD5)
d3ba39afc5dc78ef7c7ca206e1e8ce14
Author(s)
Dragoi, George
Tonegawa, Susumu
Date Issued
December 2013
Journal
eLife
Publisher
eLife Sciences Publications, Ltd.
Citation
Dragoi, G., et al. (2013). "Development of schemas revealed by prior experience and NMDA receptor knock-out." eLife 2013;2:e01326.
Version
Final published version
Abstract
Prior experience accelerates acquisition of novel, related information through processes like assimilation into mental schemas, but the underlying neuronal mechanisms are poorly understood. We investigated the roles that prior experience and hippocampal CA3 N-Methyl-D-aspartate receptor (NMDAR)-dependent synaptic plasticity play in CA1 place cell sequence encoding and learning during novel spatial experiences. We found that specific representations of de novo experiences on linear environments were formed on a framework of pre configured network activity expressed in the preceding sleep and were rapidly, flexibly adjusted via NMDAR-dependent activity. This prior experience accelerated encoding of subsequent experiences on contiguous or isolated novel tracks, significantly decreasing their NMDAR-dependence. Similarly, de novo learning of an alternation task was facilitated by CA3 NMDARs; this experience accelerated subsequent learning of related tasks, independent of CA3 NMDARs, consistent with a schema-based learning. These results reveal the existence of distinct neuronal encoding schemes which could explain why hippocampal dysfunction results in anterograde amnesia while sparing recollection of old, schema-based memories.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Picower Institute for Learning and Memory
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Creative Commons Attribution
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DOI of Published Version
https://doi.org/10.7554/eLife.01326
