One-Flow, Multi-Step Synthesis of Nucleosides via Brønsted Acid- Catalyzed Glycosylation
Name
AS MWB TFJ ACIE 2010.pdf
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677.37 KB
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Adobe PDF
Checksum (MD5)
19dbccd31caceea0f66d2bc46aa36b72
Author(s)
Sniady, Adam
Bedore, Matthew W.
Jamison, Timothy F.
Date Issued
January 2011
Journal
Angewandte Chemie International Edition
Publisher
Wiley Blackwell
Citation
Sniady, Adam, Matthew W. Bedore, and Timothy F. Jamison. “One-Flow, Multistep Synthesis of Nucleosides by Brønsted Acid-Catalyzed Glycosylation.” Angewandte Chemie International Edition 50.9 (2011): 2155–2158.
Version
Author's final manuscript
Abstract
Nucleosides in flow: A general, scalable method of Brønsted acid-catalyzed nucleoside formation is described. Because of the high reaction temperatures readily available to the flow reaction format, mild Brønsted acids, particularly pyridinium triflates, can be used. A one-flow multistep synthesis of unprotected nucleosides is also reported (see scheme).
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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Creative Commons Attribution-Noncommercial-Share Alike 3.0
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DOI of Published Version
https://doi.org/10.1002/anie.201006440
