Measurement and Modeling of Signaling at the Single-Cell Level
Name
Kolitz Biochem.pdf
Description
Main article
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458.16 KB
Format
Adobe PDF
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764edefe2d1103ddfe8c0a74192d1202
Author(s)
Kolitz, Sarah
Lauffenburger, Douglas A.
Date Issued
September 2012
Journal
Biochemistry
Publisher
American Chemical Society (ACS)
Citation
Kolitz, Sarah E., and Douglas A. Lauffenburger. “Measurement and Modeling of Signaling at the Single-Cell Level.” Biochemistry 51, no. 38 (September 25, 2012): 7433–7443.
Version
Author's final manuscript
Abstract
It has long been recognized that a deeper understanding of cell function, with respect to execution of phenotypic behaviors and their regulation by the extracellular environment, is likely to be achieved by analyzing the underlying molecular processes for individual cells selected from across a population, rather than averages of many cells comprising that population. In recent years, experimental and computational methods for undertaking these analyses have advanced rapidly. In this review, we provide a perspective on both measurement and modeling facets of biochemistry at a single-cell level. Our central focus is on receptor-mediated signaling networks that regulate cell phenotypic functions.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1021/bi300846p
