Molding immortality from a plastic germline
Name
nihms-1817609.pdf
Description
Accepted version
Size
1.13 MB
Format
Adobe PDF
Checksum (MD5)
b6b7b37e7a9e6caa90c140a91dfbf277
Author(s)
Raz, Amelie A
Yamashita, Yukiko M
Date Issued
2021
Journal
Current Opinion in Cell Biology
Publisher
Elsevier BV
Citation
Raz, Amelie A and Yamashita, Yukiko M. 2021. "Molding immortality from a plastic germline." Current Opinion in Cell Biology, 73.
Version
Author's final manuscript
Abstract
Germ cells are uniquely capable of maintaining cellular immortality, allowing them to give rise to new individuals in generation after generation. Recent studies have identified that the germline state is plastic, with frequent interconversion between germline differentiation states and across the germline/soma border. Therefore, features that grant germline immortality must be inducible, with other cells undergoing some form of rejuvenation to a germline state. In this review, we summarize the breadth of our current interpretations of germline plasticity and the ways in which these fate conversion events can aid our understanding of the underlying hallmarks of germline immortality.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/J.CEB.2021.04.010
