A Perspective on the Clinical Translation of Scaffolds for Tissue Engineering
Name
10439_2014_1104_ReferencePDF.pdf
Size
481.22 KB
Format
Adobe PDF
Checksum (MD5)
2dcee0805013d3a0bea397d2db6265c0
Author(s)
Tang, Benjamin C.
Webber, Matthew
Langer, Robert S
Khan, Omar Fizal
Sydlik, Stefanie Arlene
Date Issued
September 2014
Journal
Annals of Biomedical Engineering
Publisher
Springer US
Citation
Webber, Matthew J., Omar F. Khan, Stefanie A. Sydlik, Benjamin C. Tang, and Robert Langer. “A Perspective on the Clinical Translation of Scaffolds for Tissue Engineering.” Ann Biomed Eng 43, no. 3 (September 9, 2014): 641–656.
Version
Author's final manuscript
Abstract
Scaffolds have been broadly applied within tissue engineering and regenerative medicine to regenerate, replace, or augment diseased or damaged tissue. For a scaffold to perform optimally, several design considerations must be addressed, with an eye toward the eventual form, function, and tissue site. The chemical and mechanical properties of the scaffold must be tuned to optimize the interaction with cells and surrounding tissues. For complex tissue engineering, mass transport limitations, vascularization, and host tissue integration are important considerations. As the tissue architecture to be replaced becomes more complex and hierarchical, scaffold design must also match this complexity to recapitulate a functioning tissue. We outline these design constraints and highlight creative and emerging strategies to overcome limitations and modulate scaffold properties for optimal regeneration. We also highlight some of the most advanced strategies that have seen clinical application and discuss the hurdles that must be overcome for clinical use and commercialization of tissue engineering technologies. Finally, we provide a perspective on the future of scaffolds as a functional contributor to advancing tissue engineering and regenerative medicine.
MIT Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Chemical Engineering
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1007/s10439-014-1104-7
