Vaccine delivery with microneedle skin patches in nonhuman primates
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Hammond_Vaccine delivery.pdf
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Author(s)
Li, Adrienne Victoria
Abbink, Peter
Liu, Jinyan
Li, Hualin
Stanley, Kelly A.
Smith, Kaitlin M.
Lavine, Christy L.
Seaman, Michael S.
Kramer, Joshua A.
Miller, Andrew D.
Date Issued
December 2013
Journal
Nature Biotechnology
Publisher
Nature Publishing Group
Citation
DeMuth, Peter C, Adrienne V Li, Peter Abbink, Jinyan Liu, Hualin Li, Kelly A Stanley, Kaitlin M Smith, et al. “Vaccine Delivery with Microneedle Skin Patches in Nonhuman Primates.” Nature Biotechnology 31, no. 12 (December 6, 2013): 1082–1085.
Version
Author's final manuscript
Abstract
Transcutaneous drug delivery from planar skin patches is effective for small-molecule drugs and skin-permeable vaccine adjuvants. However, to achieve efficient delivery of vaccines and other macromolecular therapeutics into the skin, penetration of the stratum corneum is needed. Topically applied skin patches with micron-scale projections ('microneedles') pierce the upper layers of the skin and enable vaccines that are coated on or encapsulated within the microneedles to be dispersed into the skin. Although millimeter-scale syringes have shown promise for vaccine delivery in humans and technologies, such as the Dermaroller (Dermaroller, Wolfenbüttel, Germany), exist for creating microscale punctures in the skin for delivery of solutions of therapeutics, solid microprojection microneedles coated with dry vaccine formulations offer a number of valuable features for vaccination, including reduced risk of blood-borne pathogen transmission or needle-stick injury, the potential for vaccine administration by minimally trained personnel or even self administration and the use of solid-state vaccine formulations that may reduce or eliminate cold-chain requirements in vaccine distribution. Recent studies in mice have demonstrated the ability of microneedles to effectively deliver vaccines to the skin, eliciting protective immunity to influenza, hepatitis C and West Nile virus.
MIT Department
Massachusetts Institute of Technology. Institute for Soldier Nanotechnologies
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Materials Science and Engineering
Koch Institute for Integrative Cancer Research at MIT
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DOI of Published Version
https://doi.org/10.1038/nbt.2759
