Centrosome-centric view of asymmetric stem cell division
Name
rsob.200314.pdf
Description
Published version
Size
925.18 KB
Format
Adobe PDF
Checksum (MD5)
87ef95dbf85a69c46ac7c3c93fca66b6
Author(s)
Chen, Cuie
Yamashita, Yukiko M
Date Issued
2021
Journal
Open Biology
Publisher
The Royal Society
Version
Final published version
Abstract
© 2021 The Authors. The centrosome is a unique organelle: the semi-conservative nature of its duplication generates an inherent asymmetry between 'mother' and 'daughter' centrosomes, which differ in their age. This asymmetry has captivated many cell biologists, but its meaning has remained enigmatic. In the last two decades, many stem cell types have been shown to display stereotypical inheritance of either the mother or daughter centrosome. These observations have led to speculation that the mother and daughter centrosomes bear distinct information, contributing to differential cell fates during asymmetric cell divisions. This review summarizes recent progress and discusses how centrosome asymmetry may promote asymmetric fates during stem cell divisions.
MIT Department
Whitehead Institute for Biomedical Research
Massachusetts Institute of Technology. Department of Biology
Howard Hughes Medical Institute
Terms of Use
Creative Commons Attribution 4.0 International license
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1098/rsob.200314
