H3.3 Nucleosome Assembly Mutants Display a Late-Onset Maternal Effect
Name
nihms-1589080.pdf
Description
Accepted version
Size
2.12 MB
Format
Adobe PDF
Checksum (MD5)
218299a0587392e8ef66a0994bea5eda
Author(s)
Burkhart, Kirk B
Sando, Steven R
Corrionero, Anna
Horvitz, H Robert
Date Issued
2020
Journal
Current Biology
Publisher
Elsevier BV
Version
Author's final manuscript
Abstract
© 2020 Elsevier Inc. Burkhart et al. show that mutants lacking components of H3.3 assembly complexes have pleiotropic defects that manifest near the onset of adulthood. Mitochondrial stress likely contributes to these late-onset defects. The late-onset defects of H3.3 assembly mutants can be maternally rescued.
MIT Department
Howard Hughes Medical Institute
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/J.CUB.2020.04.046
