Dynamic Nuclear Polarization of [superscript 17] O: Direct Polarization
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Griffin_Dynamic nuclear pol.pdf
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3.01 MB
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Adobe PDF
Checksum (MD5)
09cb1e1319d7c1fcf4f4d33b6dcac9a6
Author(s)
Michaelis, Vladimir K.
Smith, Albert A.
Corzilius, Bjorn
Griffin, Robert Guy
Date Issued
November 2013
Journal
Journal of Physical Chemistry B
Publisher
American Chemical Society (ACS)
Citation
Michaelis, Vladimir K., Bjorn Corzilius, Albert A. Smith, and Robert G. Griffin. “Dynamic Nuclear Polarization of [superscript 17] O: Direct Polarization .” The Journal of Physical Chemistry B (November 22, 2013).
Version
Author's final manuscript
Abstract
Dynamic nuclear polarization of [superscript 17]O was studied using four different polarizing agents: the biradical TOTAPOL and the monoradicals trityl and SA-BDPA, as well as a mixture of the latter two. Field profiles, DNP mechanisms, and enhancements were measured to better understand and optimize directly polarizing this low-gamma quadrupolar nucleus using both mono- and biradical polarizing agents. Enhancements were recorded at <88 K and were >100 using the trityl (OX063) radical and <10 with the other polarizing agents. The >10 000-fold savings in acquisition time enabled a series of biologically relevant small molecules to be studied with small sample sizes and the measurement of various quadrupolar parameters. The results are discussed with comparison to room temperature studies and GIPAW quantum chemical calculations. These experimental results illustrate the strength of high field DNP and the importance of radical selection for studying low-gamma nuclei.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
Francis Bitter Magnet Laboratory (Massachusetts Institute of Technology)
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1021/jp408440z
