The Mutational Landscape of Circulating Tumor Cells in Multiple Myeloma
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Mishima-2017-The Mutational Landscape of Circu.pdf
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Author(s)
Mishima, Yuji
Paiva, Bruno
Shi, Jiantao
Park, Jihye
Manier, Salomon
Takagi, Satoshi
Massoud, Mira
Perilla-Glen, Adriana
Aljawai, Yosra
Huynh, Daisy
Date Issued
April 2017
Journal
Cell Reports
Publisher
Elsevier
Citation
Mishima, Yuji; Paiva, Bruno; Shi, Jiantao; Park, Jihye; Manier, Salomon; Takagi, Satoshi; Massoud, Mira et al. “The Mutational Landscape of Circulating Tumor Cells in Multiple Myeloma.” Cell Reports 19, no. 1 (April 2017): 218–224 © 2017 The Authors
Version
Final published version
Abstract
The development of sensitive and non-invasive “liquid biopsies” presents new opportunities for longitudinal monitoring of tumor dissemination and clonal evolution. The number of circulating tumor cells (CTCs) is prognostic in multiple myeloma (MM), but there is little information on their genetic features. Here, we have analyzed the genomic landscape of CTCs from 29 MM patients, including eight cases with matched/paired bone marrow (BM) tumor cells. Our results show that 100% of clonal mutations in patient BM were detected in CTCs and that 99% of clonal mutations in CTCs were present in BM MM. These include typical driver mutations in MM such as in KRAS, NRAS, or BRAF. These data suggest that BM and CTC samples have similar clonal structures, as discordances between the two were restricted to subclonal mutations. Accordingly, our results pave the way for potentially less invasive mutation screening of MM patients through characterization of CTCs.
MIT Department
Broad Institute of MIT and Harvard
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Creative Commons Attribution-NonCommercial-NoDerivs License
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DOI of Published Version
https://doi.org/10.1016/j.celrep.2017.03.025
