3D Bioprinting for Tissue and Organ Fabrication
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10439_2016_Article_1612.pdf
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6.3 MB
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Author(s)
Oklu, Rahmi
Zhang, Yu Shrike
Yue, Kan
Aleman, Julio
Mollazadeh-Moghaddam, Kamyar
Bakht, Syeda Mahwish
Yang, Jingzhou
Jia, Weitao
Dell’Erba, Valeria
Assawes, Pribpandao
Date Issued
April 2016
Journal
Annals of Biomedical Engineering
Publisher
Springer US
Citation
Zhang, Yu Shrike et al. “3D Bioprinting for Tissue and Organ Fabrication.” Annals of Biomedical Engineering (2016): n. pag.
Version
Author's final manuscript
Abstract
The field of regenerative medicine has progressed tremendously over the past few decades in its ability to fabricate functional tissue substitutes. Conventional approaches based on scaffolding and microengineering are limited in their capacity of producing tissue constructs with precise biomimetic properties. Three-dimensional (3D) bioprinting technology, on the other hand, promises to bridge the divergence between artificially engineered tissue constructs and native tissues. In a sense, 3D bioprinting offers unprecedented versatility to co-deliver cells and biomaterials with precise control over their compositions, spatial distributions, and architectural accuracy, therefore achieving detailed or even personalized recapitulation of the fine shape, structure, and architecture of target tissues and organs. Here we briefly describe recent progresses of 3D bioprinting technology and associated bioinks suitable for the printing process. We then focus on the applications of this technology in fabrication of biomimetic constructs of several representative tissues and organs, including blood vessel, heart, liver, and cartilage. We finally conclude with future challenges in 3D bioprinting as well as potential solutions for further development.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1007/s10439-016-1612-8
