Response Features of Parvalbumin-Expressing Interneurons Suggest Precise Roles for Subtypes of Inhibition in Visual Cortex
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Runyan-2010-Response Features of.pdf
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Author(s)
Runyan, Caroline A.
Schummers, James
Van Wart, Audra
Kuhlman, Sandra J.
Wilson, Nathan R.
Huang, Z. Josh
Sur, Mriganka
Date Issued
September 2010
Journal
Neuron
Publisher
Elsevier
Citation
Runyan, Caroline A., James Schummers, Audra Van Wart, Sandra J. Kuhlman, Nathan R. Wilson, Z. Josh Huang, and Mriganka Sur. “Response Features of Parvalbumin-Expressing Interneurons Suggest Precise Roles for Subtypes of Inhibition in Visual Cortex.” Neuron 67, no. 5 (September 9, 2010): 847–857. © 2010 Elsevier Inc
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Final published version
Abstract
Inhibitory interneurons in the cerebral cortex include a vast array of subtypes, varying in their molecular signatures, electrophysiological properties, and connectivity patterns. This diversity suggests that individual inhibitory classes have unique roles in cortical circuits; however, their characterization to date has been limited to broad classifications including many subtypes. We used the Cre/LoxP system, specifically labeling parvalbumin(PV)-expressing interneurons in visual cortex of PV-Cre mice with red fluorescent protein (RFP), followed by targeted loose-patch recordings and two-photon imaging of calcium responses in vivo to characterize the visual receptive field properties of these cells. Despite their relative molecular and morphological homogeneity, we find that PV[superscript +] neurons have a diversity of feature-specific visual responses that include sharp orientation and direction-selectivity, small receptive fields, and band-pass spatial frequency tuning. These results suggest that subsets of parvalbumin interneurons are components of specific cortical networks and that perisomatic inhibition contributes to the generation of precise response properties.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
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DOI of Published Version
https://doi.org/10.1016/j.neuron.2010.08.006
