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Analysis diffusion and glycation rate of artery in high concentration sugar condition via autofluorescence of advanced glycation end productions
Name
112150D.pdf
Description
Published version
Size
760.24 KB
Format
Adobe PDF
Checksum (MD5)
09480e2983ca7adfce8301d46a819462
Author(s)
Lin, Chih-Ju
Kang, Jeon Woong
So, Peter T. C.
Dong, Chen-Yuan
Date Issued
February 25, 2020
Journal
Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Publisher
SPIE
Citation
Lin, Chih-Ju, Kang, Jeon Woong, So, Peter T. C. and Dong, Chen-Yuan. 2020. "Analysis diffusion and glycation rate of artery in high concentration sugar condition via autofluorescence of advanced glycation end productions." Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 11215.
Version
Final published version
Abstract
© COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only. Cardiovascular complication is a major health concern for diabetic patients. Elevated blood sugar levels lead to the formation of advanced glycation end products (AGEs), which are implicated in diabetic pathogenesis. In this study, we investigate the effect of prolonged exposure to elevated sugar level by studying the combined effect of diffusion and glycation rate in arteries from different commonly-consumed simple sugars. Since some AGEs are autofluorescent, we will perform multiphoton autofluorescence imaging to quantify the rates of fluorescent AGEs formation in elastic fibers and collagen fibers. Croß-section imaging of arteries and spatial and temporal profiles of autofluorescence of the blood veßel will be investigated.
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
10.1117/12.2545589
