Y MAP: a pipeline for visualization of copy number variation and loss of heterozygosity in eukaryotic pathogens
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s13073-014-0100-8.pdf
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2.08 MB
Format
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Checksum (MD5)
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Author(s)
Abbey, Darren A.
Funt, Jason
Lurie-Weinberger, Mor N.
Thompson, Dawn A.
Regev, Aviv
Myers, Chad L.
Berman, Judith
Alternative Title
Y[subscript MAP]: a pipeline for visualization of copy number variation and loss of heterozygosity in eukaryotic pathogens
Date Issued
November 2014
Journal
Genome Medicine
Publisher
BioMed Central Ltd
Citation
Abbey, Darren A, et al., “Y MAP: a Pipeline for Visualization of Copy Number Variation and Loss of Heterozygosity in Eukaryotic Pathogens.” Genome Medicine 6, no. 11 (2014): 100.
Version
Final published version
Abstract
The design of effective antimicrobial therapies for serious eukaryotic pathogens requires a clear understanding of their highly variable genomes. To facilitate analysis of copy number variations, single nucleotide polymorphisms and loss of heterozygosity events in these pathogens, we developed a pipeline for analyzing diverse genome-scale datasets from microarray, deep sequencing, and restriction site associated DNA sequence experiments for clinical and laboratory strains of Candida albicans, the most prevalent human fungal pathogen. The Y[subscript MAP] pipeline (http://lovelace.cs.umn.edu/Ymap/) automatically illustrates genome-wide information in a single intuitive figure and is readily modified for the analysis of other pathogens with small genomes.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution
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DOI of Published Version
https://doi.org/10.1186/s13073-014-0100-8
