Bioabsorbable polymer optical waveguides for deep-tissue photomedicine
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Nizamoglu-2016-Bioabsorbable Polymer.pdf
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Author(s)
Nizamoglu, Sedat
Gather, Malte C.
Choi, Myunghwan
Kim, Seonghoon
Kim, Ki Su
Hahn, Sei Kwang
Scarcelli, Giuliano
Randolph, Mark
Redmond, Robert W.
Yun, Seok Hyun (Andy)
Date Issued
January 2016
Journal
Nature Communications
Publisher
Nature Publishing Group
Citation
Nizamoglu, Sedat, Malte C. Gather, Matjaž Humar, Myunghwan Choi, Seonghoon Kim, Ki Su Kim, Sei Kwang Hahn, et al. “Bioabsorbable Polymer Optical Waveguides for Deep-Tissue Photomedicine.” Nat Comms 7 (January 19, 2016): 10374.
Version
Final published version
Abstract
Advances in photonics have stimulated significant progress in medicine, with many techniques now in routine clinical use. However, the finite depth of light penetration in tissue is a serious constraint to clinical utility. Here we show implantable light-delivery devices made of bio-derived or biocompatible, and biodegradable polymers. In contrast to conventional optical fibres, which must be removed from the body soon after use, the biodegradable and biocompatible waveguides may be used for long-term light delivery and need not be removed as they are gradually resorbed by the tissue. As proof of concept, we demonstrate this paradigm-shifting approach for photochemical tissue bonding (PTB). Using comb-shaped planar waveguides, we achieve a full thickness (>10 mm) wound closure of porcine skin, which represents ~10-fold extension of the tissue area achieved with conventional PTB. The results point to a new direction in photomedicine for using light in deep tissues.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
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DOI of Published Version
https://doi.org/10.1038/ncomms10374
