Choosing Clinical Variables for Risk Stratification Post-Acute Coronary Syndrome
Name
s41598-019-50933-3.pdf
Description
Published version
Size
1.19 MB
Format
Adobe PDF
Checksum (MD5)
672e72ec23d0d5b3a29058e0a899539b
Author(s)
Myers, Paul Daniel
Huang, Wei
Anderson, Frederick Arthur
Stultz, Collin M
Date Issued
October 10, 2019
Journal
Scientific reports
Publisher
Springer Science and Business Media LLC
Citation
Paul D. Myers, Wei Huang, Fred Anderson & Collin M. Stultz. "Choosing Clinical Variables for Risk Stratification Post-Acute Coronary Syndrome." Scientific reports 9 (2020): 14631 © 2019, The Author(s)
Version
Final published version
Abstract
Most risk stratification methods use expert opinion to identify a fixed number of clinical variables that have prognostic significance. In this study our goal was to develop improved metrics that utilize a variable number of input parameters. We first used Bootstrap Lasso Regression (BLR) – a Machine Learning method for selecting important variables – to identify a prognostic set of features that identify patients at high risk of death 6-months after presenting with an Acute Coronary Syndrome. Using data derived from the Global Registry of Acute Coronary Events (GRACE) we trained a logistic regression model using these features and evaluated its performance on a development set (N = 43,063) containing patients who have values for all features, and a separate dataset (N = 6,363) that contains patients who have missing feature values. The final model, Ridge Logistic Regression with Variable Inputs (RLRVI), uses imputation to estimate values for missing features. BLR identified 19 features, 8 of which appear in the GRACE score. RLRVI had modest, yet statistically significant, improvement over the standard GRACE score on both datasets. Moreover, for patients who are relatively low-risk (GRACE≤87), RLRVI had an AUC and Hazard Ratio of 0.754 and 6.27, respectively, vs. 0.688 and 2.46 for GRACE, (p < 0.007). RLRVI has improved discriminatory performance on patients who have values for the 8 GRACE features plus any subset of the 11 non-GRACE features. Our results demonstrate that BLR and data imputation can be used to obtain improved risk stratification metrics, particularly for patients who are classified as low risk using traditional methods.
Subjects
Multidisciplinary
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Massachusetts Institute of Technology. Research Laboratory of Electronics
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
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Creative Commons Attribution 4.0 International license
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DOI of Published Version
https://doi.org/10.1038/s41598-019-50933-3
