Mixing and Dispersion in Small-Scale Flow Systems
Name
KDN BS TFJ KFJ OPRD 2012.pdf
Size
1.06 MB
Format
Adobe PDF
Checksum (MD5)
6400bb975aa6da9b3d1b2d40ba4a0371
Author(s)
Nagy, Kevin David
Shen, Bo
Jamison, Timothy F.
Jensen, Klavs F.
Date Issued
January 2012
Journal
Organic Process Research & Development
Publisher
American Chemical Society (ACS)
Citation
Nagy, Kevin D. et al. “Mixing and Dispersion in Small-Scale Flow Systems.” Organic Process Research & Development 16.5 (2012): 976–981.
Version
Author's final manuscript
Abstract
Continuous flow chemistry is being used increasingly; however, without detailed knowledge of reaction engineering, it can be difficult to judge whether dispersion and mixing are important factors on reaction outcome. Understanding these effects can result in improved choices of reactor dimensions and give insight for reactor scale-up. We provide an overview of both dispersive and mixing effects in flow systems and present simple relationships for determining whether mixing or dispersion is important for a given flow system. These results are summarized in convenient charts to enable the experimentalist to identify conditions with potential mixing or dispersion problems. The information also expedites design changes, such as inclusion or changes of mixers and changes in reaction tube diameters. As a case study, application of the principles to a glycosylation reaction results in increased throughput and cleaner product profiles compared to previously reported results.
MIT Department
Novartis-MIT Center for Continuous Manufacturing
Massachusetts Institute of Technology. Department of Chemical Engineering
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1021/op200349f
