mRNA vaccine delivery using lipid nanoparticles
Name
Reichmuth, A. M., et al. Mrna Vaccine Delivery Using Lipid Nanoparticles. Ther Deliv 7 5 (2016)- 319-34.pdf
Size
1.2 MB
Format
Adobe PDF
Checksum (MD5)
36c0c03a5f74f5ad6657269f780f4e5f
Author(s)
Reichmuth, Andreas Michael
Oberli, Matthias
Jaklenec, Ana
Langer, Robert S
Blankschtein, Daniel
Date Issued
April 2016
Journal
Therapeutic Delivery
Publisher
Future Science, LTD
Citation
Reichmuth, Andreas M; Oberli, Matthias A; Jaklenec, Ana et al. “mRNA Vaccine Delivery Using Lipid Nanoparticles.” Therapeutic Delivery 7, 5 (May 2016): 319–334 © 2016 Future Science Ltd
Version
Original manuscript
Abstract
mRNA vaccines elicit a potent immune response including antibodies and cytotoxic T cells. mRNA vaccines are currently evaluated in clinical trials for cancer immunotherapy applications, but also have great potential as prophylactic vaccines. Efficient delivery of mRNA vaccines will be key for their success and translation to the clinic. Among potential nonviral vectors, lipid nanoparticles are particularly promising. Indeed, lipid nanoparticles can be synthesized with relative ease in a scalable manner, protect the mRNA against degradation, facilitate endosomal escape, can be targeted to the desired cell type by surface decoration with ligands, and as needed, can be codelivered with adjuvants.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Massachusetts Institute of Technology. Department of Chemical Engineering
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.4155/tde-2016-0006
