Computerized Assessment of Social Approach Behavior in Mouse
Name
Sur-2009-computerized assessment.pdf
Size
1.91 MB
Format
Adobe PDF
Checksum (MD5)
7dc13b266dd05ccad8a4ccb315e6f17e
Author(s)
Page, Damon T.
Kuti, Orsolya J.
Date Issued
November 2009
Journal
Frontiers in Behavioral Neuroscience
Publisher
Frontiers Research Foundation
Citation
Page, Damon. “Computerized Assessment of Social Approach Behavior in Mouse.” Frontiers in Behavioral Neuroscience 3 (2009): 1-7.
Version
Final published version
Abstract
Altered sociability is a core feature of a variety of human neurological disorders, including autism. Social behaviors may be tested in animal models, such as mice, to study the biological basis of sociability and how this is altered in neurodevelopmental disorders. A quantifiable social behavior frequently used to assess sociability in the mouse is the tendency to approach and interact with an unfamiliar mouse. Here we present a novel computer-assisted method for scoring social approach behavior in mice using a three-chambered apparatus and freely available software. We find consistent results between data scored using the computer-assisted method and a human observer, making computerized assessment a reliable, low cost, high-throughput method for testing sociability.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.3389/neuro.08.048.2009
