Design Considerations for Tumor-Targeted Nanoparticles
Name
Bawendi_Design Considerations.pdf
Size
2.26 MB
Format
Adobe PDF
Checksum (MD5)
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Author(s)
Choi, Hak Soo
Liu, Wenhao
Liu, Fangbing
Nasr, Khaled
Misra, Preeti
Bawendi, Moungi G.
Frangioni, John V.
Date Issued
November 2009
Journal
Nature Nanotechnology
Publisher
Nature Publishing Group
Citation
Choi, Hak Soo et al. “Design Considerations for Tumour-targeted Nanoparticles.” Nature Nanotechnology 5.1 (2009): 42–47. Web.
Version
Author's final manuscript
Abstract
Inorganic/organic hybrid nanoparticles are potentially useful in biomedicine, but to avoid non-specific background fluorescence and long-term toxicity, they need to be cleared from the body within a reasonable timescale1. Previously, we have shown that rigid spherical nanoparticles such as quantum dots can be cleared by the kidneys if they have a hydrodynamic diameter of approximately 5.5 nm and a zwitterionic surface charge2. Here, we show that quantum dots functionalized with high-affinity small-molecule ligands that target tumours can also be cleared by the kidneys if their hydrodynamic diameter is less than this value, which sets an upper limit of 5–10 ligands per quantum dot for renal clearance. Animal models of prostate cancer and melanoma show receptor-specific imaging and renal clearance within 4 h post-injection. This study suggests a set of design rules for the clinical translation of targeted nanoparticles that can be eliminated through the kidneys.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike 3.0
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DOI of Published Version
https://doi.org/10.1038/nnano.2009.314
