Manganese and Microbial Pathogenesis: Sequestration by the Mammalian Immune System and Utilization by Microorganisms
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Nolan_Manganese and.pdf
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3.29 MB
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Adobe PDF
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7fe4cc89e596c2169910a3199cd74bae
Author(s)
Brophy, Megan Brunjes
Nolan, Elizabeth Marie
Date Issued
January 2015
Journal
ACS Chemical Biology
Publisher
American Chemical Society (ACS)
Citation
Brophy, Megan Brunjes, and Elizabeth M. Nolan. “Manganese and Microbial Pathogenesis: Sequestration by the Mammalian Immune System and Utilization by Microorganisms.” ACS Chemical Biology 10, no. 3 (March 20, 2015): 641–651. © 2015 American Chemical Society.
Version
Final published version
Abstract
Bacterial and fungal pathogens cause a variety of infectious diseases and constitute a significant threat to public health. The human innate immune system represents the first line of defense against pathogenic microbes and employs a range of chemical artillery to combat these invaders. One important mechanism of innate immunity is the sequestration of metal ions that are essential nutrients. Manganese is one nutrient that is required for many pathogens to establish an infective lifestyle. This review summarizes recent advances in the role of manganese in the host–pathogen interaction and highlights Mn(II) sequestration by neutrophil calprotectin as well as how bacterial acquisition and utilization of manganese enables pathogenesis.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1021/cb500792b
