Complex mechanics of the heterogeneous extracellular matrix in cancer
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1-s2.0-S2352431617301694-main.pdf
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Author(s)
Malandrino, Andrea
Mak, Michael
Moeendarbary, Emadaldin
Kamm, Roger Dale
Date Issued
May 2018
Journal
Extreme Mechanics Letters
Publisher
Elsevier BV
Citation
Malandrino, Andrea, Michael Mak, Roger D. Kamm, and Emad Moeendarbary. “Complex Mechanics of the Heterogeneous Extracellular Matrix in Cancer.” Extreme Mechanics Letters 21 (May 2018): 25–34. © 2018 The Authors
Version
Final published version
Abstract
The extracellular matrix (ECM) performs many critical functions, one of which is to provide structural and mechanical integrity, and many of the constituent proteins have clear mechanical roles. The composition and structural characteristics of the ECM are widely variable among different tissues, suiting diverse functional needs. In diseased tissues, particularly solid tumors, the ECM is complex and influences disease progression. Cancer and stromal cells can significantly influence the matrix composition and structure and thus the mechanical properties of the tumor microenvironment (TME). In this review, we describe the interactions that give rise to the structural heterogeneity of the ECM and present the techniques that are widely employed to measure ECM properties and remodeling dynamics. Furthermore, we review the tools for measuring the distinct nature of cell–ECM interactions within the TME.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Mechanical Engineering
Terms of Use
Creative Commons Attribution 4.0 International License
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DOI of Published Version
https://doi.org/10.1016/J.EML.2018.02.003
