Neurons regulate synaptic strength through homeostatic scaling of active zones
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jcb_201903065(1).pdf
Description
Published version
Size
729.27 KB
Format
Adobe PDF
Checksum (MD5)
b1abe2a17be7309dd79b17ad4ebea35d
Author(s)
Cunningham, Karen L
Littleton, J. Troy
Date Issued
May 2019
Journal
The Journal of cell biology
Publisher
Rockefeller University Press
Citation
Cunningham, Karen L. and J. Troy Littleton. “Neurons regulate synaptic strength through homeostatic scaling of active zones.” The Journal of cell biology 218 (2019): 1434-1435 © 2019 The Author(s)
Version
Final published version
Abstract
How neurons stabilize their overall synaptic strength following conditions that alter synaptic morphology or function is a key question in neuronal homeostasis. In this issue, Goel et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201807165) find that neurons stabilize synaptic output despite disruptions in synapse size, active zone number, or postsynaptic function by controlling the delivery of active zone material and active zone size.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1083/JCB.201903065
