The structural basis for specific decoding of AUA by isoleucine tRNA on the ribosome
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Rajbhandary_The structural basis.pdf
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Author(s)
Voorhees, Rebecca M
Mandal, Debabrata
Neubauer, Cajetan
Koehrer, Caroline
Ramakrishnan, V.
Rajbhandary, Uttam L
Date Issued
March 2013
Journal
Nature Structural & Molecular Biology
Publisher
Nature Publishing Group
Citation
Voorhees, Rebecca M, Debabrata Mandal, Cajetan Neubauer, Caroline Köhrer, Uttam L RajBhandary, and V Ramakrishnan. “The structural basis for specific decoding of AUA by isoleucine tRNA on the ribosome.” Nature Structural & Molecular Biology 20, no. 5 (March 31, 2013): 641-643.
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Author's final manuscript
Abstract
Decoding of the AUA isoleucine codon in bacteria and archaea requires modification of a C in the anticodon wobble position of the isoleucine tRNA. Here, we report the crystal structure of the archaeal tRNA2Ile, which contains the modification agmatidine in its anticodon, in complex with the AUA codon on the 70S ribosome. The structure illustrates how agmatidine confers codon specificity for AUA over AUG.
MIT Department
Massachusetts Institute of Technology. Department of Biology
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DOI of Published Version
https://doi.org/10.1038/nsmb.2545
