The planarian wound epidermis gene equinox is required for blastema formation in regeneration
Name
s41467-022-30412-6.pdf
Description
Published version
Size
9.62 MB
Format
Adobe PDF
Checksum (MD5)
e1f38ceb651191822677809f024a76bf
Author(s)
Scimone, M Lucila
Cloutier, Jennifer K
Maybrun, Chloe L
Reddien, Peter W
Date Issued
2022
Journal
Nature Communications
Publisher
Springer Science and Business Media LLC
Citation
Scimone, M Lucila, Cloutier, Jennifer K, Maybrun, Chloe L and Reddien, Peter W. 2022. "The planarian wound epidermis gene equinox is required for blastema formation in regeneration." Nature Communications, 13 (1).
Version
Final published version
Abstract
AbstractRegeneration often involves the formation of a blastema, an outgrowth or regenerative bud formed at the plane of injury where missing tissues are produced. The mechanisms that trigger blastema formation are therefore fundamental for regeneration. Here, we identify a gene, which we named equinox, that is expressed within hours of injury in the planarian wound epidermis. equinox encodes a predicted secreted protein that is conserved in many animal phyla. Following equinox inhibition, amputated planarians fail to maintain wound-induced gene expression and to subsequently undergo blastema outgrowth. Associated with these defects is an inability to reestablish lost positional information needed for missing tissue specification. Our findings link the planarian wound epidermis, through equinox, to regeneration of positional information and blastema formation, indicating a broad regulatory role of the wound epidermis in diverse regenerative contexts.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution 4.0 International license
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1038/S41467-022-30412-6
