From stem cell to erythroblast: Regulation of red cell production at multiple levels by multiple hormones
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Lodish_From stem.pdf
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317.94 KB
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Author(s)
Flygare, Johan
Chou, Song
Lodish, Harvey F
Date Issued
March 2010
Journal
IUBMB Life
Publisher
John Wiley & Sons, Inc
Citation
Lodish, Harvey, Johan Flygare, and Song Chou. “From stem cell to erythroblast: Regulation of red cell production at multiple levels by multiple hormones.” IUBMB Life 62, no. 7 (July 19, 2010): 492-496.
Version
Author's final manuscript
Abstract
This article reviews the regulation of production of red blood cells at several levels: (1) the ability of erythropoietin and adhesion to a fibronectin matrix to stimulate the rapid production of red cells by inducing terminal proliferation and differentiation of committed erythroid CFU-E progenitors; (2) the regulated expansion of the pool of earlier BFU-E erythroid progenitors by glucocorticoids and other factors that occurs during chronic anemia or inflammation; and (3) the expansion of thehematopoietic cell pool to produce more progenitors of all hematopoietic lineages.
MIT Department
Massachusetts Institute of Technology. Department of Biology
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1002/iub.322
