The Current Concept of T[subscript H]17 Cells and Their Expanding Role in Systemic Lupus Erythematosus
Name
Perry-2011-The Current Concept of TH17 Cells.pdf
Size
617.66 KB
Format
Adobe PDF
Checksum (MD5)
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Author(s)
Perry, Daniel
Peck, Ammon B.
Carcamo, Wendy C.
Morel, Laurence
Nguyen, Cuong Q.
Alternative Title
The Current Concept of TH17 Cells and Their Expanding Role in Systemic Lupus Erythematosus
Date Issued
January 2011
Journal
Arthritis
Publisher
Hindawi Pub. Corp.
Citation
Perry, Daniel et al. “The Current Concept of T H 17 Cells and Their Expanding Role in Systemic Lupus Erythematosus.” Arthritis 2011 (2011) : 1-10.
Version
Final published version
Abstract
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a multifaceted range of symptoms affecting almost every organ system. The prototypical pathology of SLE involves the production of antinuclear antibodies and the deposition of immune complexes in basement membranes throughout the body where they induce inflammatory responses. The genetic and environmental etiologies of this process are being intensively sought, and recently, TH17 cells have been implicated in the pathogenesis of SLE. TH17 cells are CD4+ memory T cells that behave as both helper and effector cell populations functioning through their signature IL-17 cytokines. Their differentiation is distinct to either the TH1 or TH2 cell lineage, but strongly influences development of adaptive responses, including autoimmunity. This paper details the biological functions and regulation of TH17 cells, followed by an update of their expanding role in SLE.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
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Creative Commons Attribution
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DOI of Published Version
http://dx.doi.org/10.1155/2011/810649
