Immunogenicity of RNA Replicons Encoding HIV Env Immunogens Designed for Self-Assembly into Nanoparticles
Name
1-s2.0-S1525001619303673-main.pdf
Description
Published version
Size
1.64 MB
Format
Adobe PDF
Checksum (MD5)
7487bb7f05c3fd88b51c28158c3e638d
Author(s)
Melo, Mariane Bandeira
Porter, Ely
Zhang, Yuan
Silva, Murillo
Li, Na
Dobosh, Brian S
Liguori, Alessia
Skog, Pat
Landais, Elise
Menis, Sergey
Date Issued
December 2019
Journal
Molecular Therapy
Publisher
Elsevier BV
Citation
Melo, Mariane et al. "Immunogenicity of RNA Replicons Encoding HIV Env Immunogens Designed for Self-Assembly into Nanoparticles." Molecular Therapy 27, 12 (December 2019): P2080-2090 © 2019 The American Society of Gene and Cell Therapy
Version
Final published version
Abstract
Self-replicating RNAs derived from alphaviruses have high potential for vaccine applications. Utilizing lipid nanoparticle-formulated RNA replicons as a vaccine platform to deliver self-assembling protein immunogens, Melo et al. demonstrate robust anti-HIV Env antibody production and significantly improved antigen-specific B cell activation in vaccinated mice when compared with protein immunization.
MIT Department
Massachusetts Institute of Technology. Synthetic Biology Center
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Materials Science and Engineering
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.ymthe.2019.08.007
