Analytical description of Ogston-regime biomolecule separation using and nanopores
Name
Li-2009-Analytical description of Ogston-regime biomolecule separation using nanofilters and nanopores.pdf
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205.83 KB
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Author(s)
Li, Zi Rui
Liu, Gui Rong
Cheng, Yuan
Han, Jongyoon
Chen, Yu Zong
Wang, Jian-Sheng
Hadjiconstantinou, Nicolas
Date Issued
June 2009
Journal
Physical Review E
Publisher
American Physical Society
Citation
Li, Zi Rui et al. “Analytical description of Ogston-regime biomolecule separation using nanofilters and nanopores.” Physical Review E 80.4 (2009): 041911. © 2009 The American Physical Society
Version
Final published version
Abstract
We present a theoretical model describing Ogston (pore size comparable to or larger than the characteristic molecular dimension) sieving of rigid isotropic and anisotropic biomolecules in nanofluidic molecular filter arrays comprising of alternating deep and shallow regions. Starting from a quasi-one-dimensional drift-diffusion description, which captures the interplay between the driving electric force, entropic barrier and molecular diffusion, we derive explicit analytical results for the effective mobility and trapping time. Our results elucidate the effects of field strength, device geometry and entropic barrier height, providing a robust tool for the design and optimization of nanofilter/nanopore systems. Specifically, we show that Ogston sieving becomes negligible when the length of shallow region becomes sufficiently small, mainly due to efficient diffusional transport through the short shallow region. Our theoretical results are in line with experimental observations and provide important design insight for nanofluidic systems.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Massachusetts Institute of Technology. Department of Mechanical Engineering
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
http://dx.doi.org/10.1103/PhysRevE.80.041911
