Experimental and computational understanding of pulsatile release mechanism from biodegradable core-shell microparticles
Name
sciadv.abn5315.pdf
Description
Published version
Size
5.42 MB
Format
Adobe PDF
Checksum (MD5)
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Author(s)
Sarmadi, Morteza
Ta, Christina
VanLonkhuyzen, Abigail M
De Fiesta, Dominique C
Kanelli, Maria
Sadeghi, Ilin
Behrens, Adam M
Ingalls, Bailey
Menon, Nandita
Daristotle, John L
Date Issued
July 15, 2022
Journal
Science Advances
Publisher
American Association for the Advancement of Science (AAAS)
Citation
Sarmadi, Morteza, Ta, Christina, VanLonkhuyzen, Abigail M, De Fiesta, Dominique C, Kanelli, Maria et al. 2022. "Experimental and computational understanding of pulsatile release mechanism from biodegradable core-shell microparticles." Science Advances, 8 (28).
Version
Final published version
Abstract
Next-generation therapeutics require advanced drug delivery platforms with precise control over morphology and release kinetics. A recently developed microfabrication technique enables fabrication of a new class of injectable microparticles with a hollow core-shell structure that displays pulsatile release kinetics, providing such capabilities. Here, we study this technology and the resulting core-shell microstructures. We demonstrated that pulsatile release is governed by a sudden increase in porosity of the polymeric matrix, leading to the formation of a porous path connecting the core to the environment. Moreover, the release kinetics within the range studied remained primarily independent of the particle geometry but highly dependent on its composition. A qualitative technique was developed to study the pattern of pH evolution in the particles. A computational model successfully modeled deformations, indicating sudden expansion of the particle before onset of release. Results of this study contribute to the understanding and design of advanced drug delivery systems.
MIT Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
Koch Institute for Integrative Cancer Research at MIT
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Terms of Use
Creative Commons Attribution NonCommercial License 4.0
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DOI of Published Version
https://doi.org/10.1126/sciadv.abn5315
