Ena/VASP Is Required for Neuritogenesis in the Developing Cortex
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Gertler_Ena VASP is required.pdf
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Author(s)
Kwiatkowski, Adam V.
Rubinson, Douglas A.
Dent, Erik W.
Edward van Veen, J.
Leslie, Jonathan D.
Zhang, Jiangyang
Mebane, Leslie Marie
Philippar, Ulrike
Pinheiro, Elaine M.
Burds, Aurora A.
Date Issued
November 2007
Journal
Neuron
Publisher
Elsevier
Citation
Kwiatkowski, Adam V., Douglas A. Rubinson, Erik W. Dent, J. Edward van Veen, Jonathan D. Leslie, Jiangyang Zhang, Leslie M. Mebane, et al. “Ena/VASP Is Required for Neuritogenesis in the Developing Cortex.” Neuron 56, no. 3 (November 2007): 441-455. Copyright © 2007 Elsevier Inc.
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Final published version
Abstract
Mammalian cortical development involves neuronal migration and neuritogenesis; this latter process forms the structural precursors to axons and dendrites. Elucidating the pathways that regulate the cytoskeleton to drive these processes is fundamental to our understanding of cortical development. Here we show that loss of all three murine Ena/VASP proteins, a family of actin regulatory proteins, causes neuronal ectopias, alters intralayer positioning in the cortical plate, and, surprisingly, blocks axon fiber tract formation during corticogenesis. Cortical fiber tract defects in the absence of Ena/VASP arise from a failure in neurite initiation, a prerequisite for axon formation. Neurite initiation defects in Ena/VASP-deficient neurons are preceded by a failure to form bundled actin filaments and filopodia. These findings provide insight into the regulation of neurite formation and the role of the actin cytoskeleton during cortical development.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Koch Institute for Integrative Cancer Research at MIT
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1016/j.neuron.2007.09.008
