Glycan Receptor Binding of the Influenza A Virus H7N9 Hemagglutinin
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Sasisekharan_Glycan receptor.pdf
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1.58 MB
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Author(s)
Tharakaraman, Kannan
Jayaraman, Akila
Raman, Rahul
Viswanathan, Karthik
Stebbins, Nathan W.
Johnson, David Alan
Shriver, Zachary H.
Sasisekharan, Ram
Stebbins, Nathan W.
Sasisekharan, Viswanathan
Date Issued
June 2013
Journal
Cell
Publisher
Elsevier B.V.
Citation
Tharakaraman, Kannan, Akila Jayaraman, Rahul Raman, Karthik Viswanathan, Nathan W. Stebbins, David Johnson, Zachary Shriver, V. Sasisekharan, and Ram Sasisekharan. “Glycan Receptor Binding of the Influenza A Virus H7N9 Hemagglutinin.” Cell 153, no. 7 (June 2013): 1486–1493. © 2013 Elsevier B.V.
Version
Final published version
Abstract
The advent of H7N9 in early 2013 is of concern for a number of reasons, including its capability to infect humans, the lack of clarity in the etiology of infection, and because the human population does not have pre-existing immunity to the H7 subtype. Earlier sequence analyses of H7N9 hemagglutinin (HA) point to amino acid changes that predicted human receptor binding and impinge on the antigenic characteristics of the HA. Here, we report that the H7N9 HA shows limited binding to human receptors; however, should a single amino acid mutation occur, this would result in structural changes within the receptor binding site that allow for extensive binding to human receptors present in the upper respiratory tract. Furthermore, a subset of the H7N9 HA sequences demarcating coevolving amino acids appears to be in the antigenic regions of H7, which, in turn, could impact effectiveness of the current WHO-recommended prepandemic H7 vaccines.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Singapore-MIT Alliance in Research and Technology (SMART)
Koch Institute for Integrative Cancer Research at MIT
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1016/j.cell.2013.05.034
