Glycans in Virus-Host Interactions: A Structural Perspective
Name
fmolb-08-666756.pdf
Description
Published version
Size
1.18 MB
Format
Adobe PDF
Checksum (MD5)
9eb80f5230f09d3c794d5ef2aaa5cc5a
Author(s)
Miller, Nathaniel L.
Clark, Thomas
Raman, Rahul
Sasisekharan, Ram
Date Issued
June 2021
Journal
Frontiers in Molecular Biosciences
Publisher
Frontiers Media SA
Citation
Miller, Nathaniel L. et al. "Glycans in Virus-Host Interactions: A Structural Perspective." Frontiers in Molecular Biosciences 8 (June 2021): 666756.
Version
Final published version
Abstract
Many interactions between microbes and their hosts are driven or influenced by glycans, whose heterogeneous and difficult to characterize structures have led to an underappreciation of their role in these interactions compared to protein-based interactions. Glycans decorate microbe glycoproteins to enhance attachment and fusion to host cells, provide stability, and evade the host immune system. Yet, the host immune system may also target these glycans as glycoepitopes. In this review, we provide a structural perspective on the role of glycans in host-microbe interactions, focusing primarily on viral glycoproteins and their interactions with host adaptive immunity. In particular, we discuss a class of topological glycoepitopes and their interactions with topological mAbs, using the anti-HIV mAb 2G12 as the archetypical example. We further offer our view that structure-based glycan targeting strategies are ready for application to viruses beyond HIV, and present our perspective on future development in this area.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution 4.0 International license
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.3389/fmolb.2021.666756
